Title: 5-Aryl-1,3,4-thiadiazole-based Hydroxamic Acids as Histone Deacetylase Inhibitors and Antitumor Agents: Synthesis, Bioevaluation and Docking Study Authors: Vu, Duc Loi Keywords: Histone deacetylase (HDAC) inhibitors;5-aryl-1,3,4-thiadiazole;cytotoxicity;heterocycle. Issue Date: 2014 Publisher: Bentham Science Publishers Abstract: The search for newer histone deacetylase (HDAC) inhibitors has attracted a great deal of interest of medicinal chemists worldwide, especially after the first HDAC inhibitor (Zolinza ® , widely known as SAHA or Suberoylanilide hy-droxamic acid) was approved by the FDA for the treatment of T-cell lymphoma in 2006. As a continuity of our ongoing research in this area, we designed and synthesized a series of 5-aryl-1,3,4-thiadiazole-based hydroxamic acids as ana-logues of SAHA and evaluated their biological activities. Most of the compounds in this series, e.g.compounds with 5-aryl moiety being 2-furfury...
Nhận xét
Đăng nhận xét